We will survey the development, operational use, and subsequent evolution of the world's first operational cruise missile, the V-1; and the world's first operational ballistic missile, the V-2. The course will be broken into four parts: the post-WWI environment that led to development of these missiles; the V-1 cruise missile in operational service; the V-2 ballistic missile in operational service; and early US Air Force missile development based on these two designs.