In 2004 he was the first chiropractor appointed to the medical staff of the VA Connecticut Healthcare System, where he developed processes for integrating hospital-based chiropractic services and inter-professional clinical education. 

He is also an Assistant Professor at the Yale School of Medicine, section of the biomedical informatics and data science, and has authored over 70 peer-reviewed papers on topics including low back pain management, spinal manipulation, inter-professional education, and chiropractic sciences. 

Dr. Lisi is a senior member of the Clinical Practice Guidelines Development Committee of the North American Spine Society, and he received the American Chiropractic Association's 2015 Academician of the Year, 2017 Chiropractic of the Year, and 2023 Humanitarian of the Year awards.