The DSM-5-TR is designed to serve clinicians as a guide to identify the most prominent symptoms to be assessed when differentially diagnosing a mental health disorder. Clinical training and experience are needed to use the DSM-5-TR. The diagnostic criteria utilized in the DSM-5-TR identify symptoms, behaviors, cognitive functions, personality traits, physical signs, syndrome combinations, and durations that require clinical expertise to differentiate from normal life variations and transient responses to stress. Reliable diagnoses are essential for guiding not only treatment recommendations but psychopharmacology. This training presents information concerning criteria used in the differential diagnosis of mental disorders recognized in the DSM-5-TR. The training is intended to teach participants how to effectively utilize the DSM-5-TR manual. You will become familiar with the mental health disorders contained in the DSM-5-TR and will be presented opportunities to differentially diagnosis disorders utilizing practice vignettes.